I think what he means is that he would rather have the website centered, than aligned on the left side of the screen. I use a native resolution of 1920x1200 on my LCD screen and all the site's content is aligned on the left side of the screen, while the weather/time widgets are on the right side. I don't think it looks too bad, but you might want to tweak it a little so the entire site is centered. On lower resolutions it will be centered I guess, but a lot of people are using 1280x1024 or more these days.
This is how the website looks like for me in 1920x1200 (Firefox). The graphics are a little messed up as you can see.