Do you mean the wise way would be first to look on Overture (or other similar tool) what "natural" score already exists for the name (or combination) I could want.
Or even, to register a name from Overture score (for instance, when typing "wine" on Overture, I get 731,275 searches in June, with sub-repartitions for associations of "win" with f.i. accessory",...with "rack",etc...). And for every 2 words combination (I suppose all "one word" are already tacken), I go down, looking in Whois first available combination-name to register it ? Is that the way "professionals" do it here ? (but in that case, is it better f.i. winerack.com or wine-rack.com ?
But if so, what's then the breakevenpoint to register it (I mean the number of searchs equlibrating and thus justifying to disburse the registration fee) ? Is it 1,000 searches, 100 searches or 10,... ?