Regfee, I do not think the 'pixel' craze is over by a long way, it just needs to be matured in its approach to advertising.
I can see spin-offs emerging in the very near future, not pixel advertising exactly but utilizing the general idea. What we as domainers and web owners must do is be in the forefront of this maturing process. I am personally just about to bring a site online that partially uses the 'pixel' idea, but it would not pay for itself if it was just a copy, that I am sure about.
If you have an idea run with it, for you only get one shot at this life.