I'm not a fan of numbers along with many other resellers but I do see some potential with the names.
The number 1 fits well with both names. I think 1drug.com is better than 1medicine.com but I suspect 1medicine.com receives sufficient typeins (traffic stats onemedicine.com) to make it as valuable as 1drug.com
I think 1drug.com has good potential of resale to a pharmaceutical some time down the road. People who are ill seem to be fed a cocktail of drugs which can be very dangerous and expensive. Development of 1 drug to replace a cocktail of drugs would make this name attractive for advertising purposes. Owning both versions 1drug.com/onedrug.com would be preferred. I won't put a number on this but it could be significant.
1medicine.com seems a little awkward and less desirable.
However, to a reseller, the names are not attractive due to the numbers. With so much choice out there they may be considered too much of a risky investment.
Drug1.com - $250 reseller
Medicine1.com - Based on traffic $100+traffic